XtalPi launches Kodexia, a closed-loop siRNA platform combining generative AI, first-principles modeling and automated experiments

What changed

XtalPi debuted Kodexia on October 6, a closed-loop siRNA discovery platform combining generative AI, first-principles biological modeling and automated experimentation across sequence design, chemical modification, validation, extrahepatic delivery and IP strategy. The company also disclosed six proprietary preclinical programs and says its lead IgA-nephropathy program reached non-human-primate efficacy data within seven months. XtalPi reports nearly threefold design-efficiency gains and a first-round in-vivo hit rate above 50%; these are company-reported internal results rather than independent cross-platform benchmarks.